FEATURES

FAMILY

DESCRIPTION

Also known as CA1A_CONPE, CA1A. Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=7-68 nM) and alpha-7/CHRNA7 (IC(50)=253 nM) nAChRs (PubMed:8068627, PubMed:10545176, PubMed:15929983, PubMed:22024738, PubMed:25101833). It also shows a high inhibition on alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=11 nM) and a low inhibition on alpha-6-beta-4/CHRNA4-CHRNB4 (IC(50)>500 nM) (PubMed:22024738). It interacts with a hydrophobic pocket between two acetylcholine receptor subunits. In vivo, inhibits Ehrlich carcinoma growth and increase mouse survival (PubMed:32272633). These effects are greatly enhanced when the toxin is applied with the selective 12-lipoxygenase inhibitor baicalein (PubMed:32272633).

EXTERNAL LINKS

CA1A

Alpha-conotoxin PnIA

CA1A

Molecular Synopsis