FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as DHB4_HUMAN, HSD17B4, EDH17B4, SDR8C1. Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:10671535). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HSD17B4

Peroxisomal multifunctional enzyme type 2

HSD17B4

Molecular Synopsis