FEATURES

FAMILY

DESCRIPTION

Also known as CLCN7_HUMAN, CLCN7. Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). Chloride channel 7 are heteromers of alpha (CLCN7) and beta (OSTM1) subunits.

EXTERNAL LINKS

CLCN7

H(+)/Cl(-) exchange transporter 7

CLCN7

Molecular Synopsis