FEATURES

DESCRIPTION

Also known as RNLA_ECOLI, rnlA, std, yfjN. Toxic component of a type II toxin-antitoxin (TA) system (PubMed:20980243, PubMed:24112600). A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd (PubMed:20980243, PubMed:22403819). Targets cyaA mRNA (PubMed:19019153). Forms homodimer in solution (PubMed:24112600). Forms a complex with cognate antitoxin RnlB (PubMed:20980243) and with enterobacteria phage T4 antitoxin Dmd (PubMed:22403819).

EXTERNAL LINKS

uniprot
enzyme classification

rnlA

mRNA endoribonuclease toxin LS

rnlA

Molecular Synopsis