FEATURES

DESCRIPTION

Also known as VAV2_HUMAN, VAV2. Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

VAV2

Guanine nucleotide exchange factor VAV2

VAV2

Molecular Synopsis