FEATURES

FAMILY

DESCRIPTION

Also known as CATC_HUMAN, CTSC, CPPI. Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CTSC

Mutations

Mutation(s) distribution

Mutations table