FEATURES

FAMILY

DESCRIPTION

Also known as HST2_YEAST, HST2. NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export. Homotrimer. Monomer. Homotrimeric in its unliganded state. Undergoes a trimer-monomer transition upon acetyl-lysine substrate binding.

EXTERNAL LINKS

uniprot
enzyme classification

HST2

NAD-dependent protein deacetylase HST2

Mutations

Mutation(s) distribution

Mutations table

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