FEATURES

FAMILY

DESCRIPTION

Also known as TCP4_HUMAN, SUB1, PC4, RPO2TC1. General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). Homodimer. Interacts with CSTF2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SUB1

Activated RNA polymerase II transcriptional coactivator p15

Mutations

Mutation(s) distribution

Mutations table

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