FEATURES

FAMILY

DESCRIPTION

Also known as HIRA_HUMAN, HIRA, DGCR1, HIR, TUPLE1. Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with histone H3-3B, PAX3 and PAX7 (By similarity). Interacts with histone H3.Y (PubMed:28334823). Interacts with CCNA1, HIRIP3, NFU1/HIRIP5 and histone H2B. Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1 (PubMed:11238922, PubMed:14680630, PubMed:14718166, PubMed:15621527, PubMed:16980972, PubMed:19029251, PubMed:9710638).

Also known as HIRA_HUMAN, HIRA, DGCR1, HIR, TUPLE1. Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription ...

EXTERNAL LINKS

HIRA

Protein HIRA

HIRA

Molecular Synopsis