FEATURES

FAMILY

DESCRIPTION

Also known as MNTR_BACSU, mntR, yqhN. Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems (PubMed:27748968, PubMed:10760146, PubMed:12950915). In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes (PubMed:27748968, PubMed:12950915). The manganese concentration required for activation of efflux is higher than that for repression of uptake (PubMed:27748968). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

mntR

HTH-type transcriptional regulator MntR

mntR

Molecular Synopsis