FEATURES

FAMILY

DESCRIPTION

Also known as CBH_CLOPE, cbh. Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in major human bile salts, such as glycocholate (GCA), taurocholate (TCA) and taurodeoxycholate (TDCA) (PubMed:7618863, PubMed:15823032). Shows a slight preference for taurine-conjugated bile acids as substrates (PubMed:7618863). Homotetramer (PubMed:7618863, PubMed:15823032). The tetramer consists of a dimer of dimers (PubMed:15823032).

EXTERNAL LINKS

uniprot
enzyme classification

cbh

Conjugated bile acid hydrolase

cbh

Molecular Synopsis