FEATURES

FAMILY

DESCRIPTION

Also known as DRG2_HUMAN, DRG2. Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Interacts with RWDD1; this interaction confers protection to polyubiquitination and proteolytic degradation (By similarity). Interacts with JMJD7; this interaction is direct (PubMed:29915238).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DRG2

Developmentally-regulated GTP-binding protein 2

DRG2

Molecular Synopsis