FEATURES

FAMILY

DESCRIPTION

Also known as ITA1_HUMAN, ITGA1. Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21. Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ITGA1

Mutations

Mutation(s) distribution

Mutations table