FEATURES

FAMILY

DESCRIPTION

Also known as TO1A_HADVE, TO1A. Reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels in cockroach DUM neurons (PubMed:17610847). Lethal to many insect species but not toxic to mammals (PubMed:9228949). May target the insect high-voltage-activated calcium channel Dmca1D. Also inhibits acarines calcium channels. An extremely high toxin concentration partially inhibits Cav1.2/CACNA1C, Cav2.1/CACNA1A and Cav2.2/CACNA1B calcium channel of rats. As for omega-AcTx-Hv2a, the phenotypic effect of injection of this toxin into lone star ticks (Amblyomma americanum) is curling of all eight legs into closed loops.

EXTERNAL LINKS

uniprot
enzyme classification

TO1A

Omega-hexatoxin-Hv1a

TO1A

Molecular Synopsis