FEATURES

FAMILY

DESCRIPTION

Also known as TX1_STRGF, TX1. Reversibly inhibits potassium currents in oocytes expressing Kv2.1/KCNB1 channels (Kd=2.7 uM) (PubMed:15051809). Acts by shifting activation of the channel to more depolarized voltages. The toxin may bind to the S3b-S4 helices of the voltage sensor paddle. One, two, three or four toxin molecules may bind the Kv2.1/KCNB1 channel. It shows low to moderate affinity for lipid bilayers (PubMed:29703751). It partitions into the bilayer membrane, where it stabilizes at the water/membrane interface (PubMed:17071657, PubMed:20643084).

EXTERNAL LINKS

uniprot
enzyme classification

TX1

Kappa-theraphotoxin-Scg1a

TX1

Molecular Synopsis