FEATURES

FAMILY

DESCRIPTION

Also known as ASM3B_MOUSE, Smpdl3b, Asml3b. Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity (PubMed:26095358). Acts as a negative regulator of Toll-like receptor signaling (PubMed:26095358, PubMed:27687724). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358, PubMed:27687724). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (PubMed:27687724). Interacts with TLR4, TLR7, TLR8 and TLR9.

EXTERNAL LINKS

uniprot
enzyme classification

Smpdl3b

Acid sphingomyelinase-like phosphodiesterase 3b

Smpdl3b

Molecular Synopsis