FEATURES

FAMILY

DESCRIPTION

Also known as PA2B8_DABRR, PA2B8. Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

PA2B8

Basic phospholipase A2 VRV-PL-VIIIa

PA2B8

Molecular Synopsis