FEATURES

FAMILY

DESCRIPTION

Also known as KAX54_HOTTA, KAX54. Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061).

EXTERNAL LINKS

uniprot
enzyme classification

KAX54

Potassium channel toxin alpha-KTx 5.4

Mutations

Mutation(s) distribution

Mutations table

Search Mutation