FEATURES

FAMILY

DESCRIPTION

Also known as RAB14_HUMAN, RAB14. Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Interacts with KIF16B (By similarity). Interacts with ZFYVE20.

EXTERNAL LINKS

RAB14

Mutations

Mutation(s) distribution

Mutations table