FEATURES

FAMILY

DESCRIPTION

Also known as RAP1B_HUMAN, RAP1B. GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Interacts with KRIT1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RAP1B

Mutations

Mutation(s) distribution

Mutations table