FEATURES

FAMILY

pterin-4-alpha-carbinolamine dehydratase family

DESCRIPTION

Also known as PHS_RAT, Pcbd1, Dcoh, Pcbd. Involved in tetrahydrobiopterin biosynthesis (PubMed:8444860, PubMed:8618906). Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (PubMed:8444860). Coactivator for HNF1A-dependent transcription (PubMed:1763325). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (PubMed:1763325). Also acts as a coactivator for HNF1B-dependent transcription (By similarity). Homotetramer and homodimer (PubMed:1763325, PubMed:8444860, PubMed:10966642, PubMed:7744010, PubMed:8897596). Heterotetramer with HNF1A; formed by a dimer of dimers (PubMed:10966642). Interacts with HNF1B (via HNF-p1 domain); the interaction increases HNF1B transactivation activity (By similarity).

EXTERNAL LINKS

Pcbd1

Structural Ligandability

Domains Chains

Distribution