FEATURES

FAMILY

DESCRIPTION

Also known as BLAT_ECOLX, bla, blaT-3, blaT-4, blaT-5, blaT-6. TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.

EXTERNAL LINKS

uniprot
enzyme classification

bla, blaT-3, blaT-4, blaT-5, blaT-6

Beta-lactamase TEM

bla, blaT-3, blaT-4, blaT-5, blaT-6

Molecular Synopsis