FEATURES

FAMILY

DESCRIPTION

Also known as H4_MOUSE, H4c1, H4c2, H4c3, H4c4, H4c6, H4c8, H4c9, H4c11, H4c12, Hist1h4m, H4c14, H4f16, Hist1h4a, H4-53, Hist1h4b, H4-12, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist2h4, Hist2h4a, Hist4h4. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).

Also known as H4_MOUSE, H4c1, H4c2, H4c3, H4c4, H4c6, H4c8, H4c9, H4c11, H4c12, Hist1h4m, H4c14, H4f16, Hist1h4a, H4-53, Hist1h4b, H4-12, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, H ...

EXTERNAL LINKS

H4c1, H4c2, H4c3, H4c4, H4c6, H4c8, H4c9, H4c11, H4c12, Hist1h4m, H4c14, H4f16

Histone H4

H4c1, H4c2, H4c3, H4c4, H4c6, H4c8, H4c9, H4c11, H4c12, Hist1h4m, H4c14, H4f16

Molecular Synopsis