FEATURES

FAMILY

DESCRIPTION

Also known as SDHE_ECO57, sdhE, ygfY. An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

sdhE

FAD assembly factor SdhE

sdhE

Molecular Synopsis