FEATURES

FAMILY

DESCRIPTION

Also known as MLAD_ECOLI, mlaD, yrbD. Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane (PubMed:19383799, PubMed:27529189). MlaD functions in substrate binding with strong affinity for phospholipids and modulates ATP hydrolytic activity of the complex (PubMed:27529189). The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD) (PubMed:27529189, PubMed:28388411). Interacts with MlaC (PubMed:28388411).

EXTERNAL LINKS

mlaD

Mutations

Mutation(s) distribution

Mutations table