FEATURES

FAMILY

DESCRIPTION

Also known as K7_VACCW, K7R. Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation. Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation. Interacts with DDDX3; this interaction inhibits DDX3 and suppresses DDX3-mediated IFN-beta promoter induction. Interacts with TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB activation.

EXTERNAL LINKS

uniprot
enzyme classification

K7R

Protein K7

K7R

Molecular Synopsis