FEATURES

FAMILY

DESCRIPTION

Also known as AUR25_RANAE, AUR25. Amphipathic alpha-helical antimicrobial peptide with moderate to potent activity against Gram-positive bacteria, Gram-negative bacteria and fungi (PubMed:10951191, PubMed:19056250, PubMed:23841919, PubMed:24728560, PubMed:31358802). Shows also a weak activity against biofilm of both Gram-positive and Gram-negative bacteria (PubMed:19056250). Probably acts by disturbing membrane functions with its amphipathic structure (PubMed:10951191, PubMed:23841919). Kills fungi via membranolytic action (PubMed:24728560). Enhanced sterol levels in lipid composition membranes reduce interaction of this peptide with membranes, having a protective effect against the lytic ability of the peptide (PubMed:24728560). Shows anticancer activity (PubMed:10951191). May be monomeric or may oligomerize as homodimers or homotrimers in Gram-positive and Gram-negative bacteria mimetic membranes.

EXTERNAL LINKS

AUR25

Mutations

Mutation(s) distribution

Mutations table