FEATURES

FAMILY

DESCRIPTION

Also known as US28_HCMVA, US28. Receptor for a C-C type chemokine. Binds to a number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine. Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages. The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis. Interacts with endogenous Gaq/11 subunits and thereby constitutively activates phospholipase C. Interacts with host GPRASP1; this interaction targets US28 to lysosomes for degradation.

EXTERNAL LINKS

US28

G-protein coupled receptor homolog US28

US28

Molecular Synopsis