FEATURES

FAMILY

ammonia transporter channel (TC 1.A.11.2) family

DESCRIPTION

Also known as AMTB_ECOLI, amtB, ybaG. Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)) (PubMed:14668330, PubMed:15876187, PubMed:15563598, PubMed:15361618, PubMed:16910683, PubMed:30211659, PubMed:32662768). Transport is electrogenic (PubMed:30211659, PubMed:32662768). Following sequestration of NH(4)(+) at the periplasmic face, NH(4)(+) is deprotonated and neutral NH(3) is transported into the cytoplasm (PubMed:15876187, PubMed:16910683, PubMed:18362341, PubMed:19278252, PubMed:32662768). Neutral NH(3) and charged H(+) are carried separately across the membrane on a unique two-lane pathway, before recombining to NH(4)(+) inside the cell (PubMed:32662768). In vitro can also transport the larger analogs methylamine and methylammonium (PubMed:11847102, PubMed:14668330, PubMed:12023896, PubMed:15876187, PubMed:17998534, PubMed:18362341). Also acts as a sensor of the extracellular ammonium concentration (PubMed:14668330). Homotrimer (PubMed:12023896, PubMed:15563598, PubMed:15361618, PubMed:17040913). In response to elevation of the extracellular ammonium concentration, interacts and forms a complex with GlnK (PubMed:10637624, PubMed:11847102, PubMed:14668330, PubMed:17220269, PubMed:17190799, PubMed:16864585, PubMed:20639578). Interacts with GlnK with a stoichiometry of AmtB(3):GlnK(3) (PubMed:17220269, PubMed:17190799). Sequestration of GlnK is reversible (PubMed:14668330).

Also known as AMTB_ECOLI, amtB, ybaG. Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)) (PubMed:14668330, PubMed:15876187, PubMed:15563598, PubMed:15361618, PubMed:16910683, PubMed:30 ...

EXTERNAL LINKS

amtB

Mutations

Mutation(s) distribution

Mutations table