FEATURES

FAMILY

DESCRIPTION

Also known as DCEB_ECOLI, gadB. Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria. Homohexamer composed of three dimers.

EXTERNAL LINKS

uniprot
enzyme classification

gadB

Glutamate decarboxylase beta

gadB

Molecular Synopsis