FEATURES

DESCRIPTION

Also known as PI51B_MOUSE, Pip5k1b. Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8798574, PubMed:9367159, PubMed:9535851, PubMed:22942276). PtdIns(4, 5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1, 4, 5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments (PubMed:10679324). Contributes to the activation of phospholipase PLD2 (PubMed:11032811). Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (PubMed:18772378). Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1.

Pip5k1b

Structural Ligandability

Domains Chains

Distribution