FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as MABA_MYCS2, mabA, fabG. Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis (By similarity). Catalyzes the NADPH-dependent reduction of beta-ketoacyl derivatives, the second step of the FAS-II elongation cycle (By similarity). Has a preference for longer substrates (PubMed:29717709). Can use CoA derivatives as substrates in vitro (PubMed:29717709). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

mabA

3-oxoacyl-[acyl-carrier-protein] reductase MabA

mabA

Molecular Synopsis