FEATURES

DESCRIPTION

Also known as SPTP_SALTY, sptP. Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear. Forms a complex with SicP. Binds host RAC1.

EXTERNAL LINKS

uniprot
enzyme classification

sptP

Secreted effector protein SptP

sptP

Molecular Synopsis