FEATURES

FAMILY

DESCRIPTION

Also known as FSAA_ECOLI, fsaA, fsa, mipB, ybiZ. Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1, 7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1, 6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity. Homodecamer. Five subunits are arranged as a pentamer, and two ring-like pentamers pack like a donut to form the decamer.

EXTERNAL LINKS

fsaA

Fructose-6-phosphate aldolase 1

fsaA

Molecular Synopsis