FEATURES

FAMILY

DESCRIPTION

Also known as DRS4_PHYSA, DRS4. Potent antimicrobial peptide with activity against bacteria and protozoa (By similarity). Also has activity against fungi (PubMed:8306981). Also shows activity against enveloped herpes simplex virus type 1 (PubMed:11782932). Probably acts by disturbing membrane functions with its amphipathic structure (Probable). Binds to healthy erythrocytes (this binding is receptor independent), and has strong hemolytic activity (PubMed:9395500). Does not bind to P.falciparum infected erythrocytes, but accumulates within the parasite (PubMed:9395500). Kills the parasite, and only at high concentrations has a hemolytic activity on the host cell (PubMed:9395500). In vitro, shows high spermicidal activities (PubMed:16307969). Monomer and oligomer. Forms aggregates in aqueous environments.

EXTERNAL LINKS

DRS4

Dermaseptin-S4

DRS4

Molecular Synopsis