FEATURES

FAMILY

DESCRIPTION

Also known as LEUC_METJA, leuC. Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate. Heterotetramer of 2 LeuC and 2 LeuD. Cannot form a complex with HacB.

EXTERNAL LINKS

uniprot
enzyme classification

leuC

Isopropylmalate/citramalate isomerase large subunit

leuC

Molecular Synopsis