FEATURES

FAMILY

Potassium channel inhibitor kappa-KTx family

DESCRIPTION

Also known as KKX11_CHEFU, KKX11. Shows weak blocking activity on voltage-gated potassium channels Kv10.1/KCNH1/EAG1 (IC(50)=26 uM), Kv1.2/KCNA2 (Kd=150 uM), Kv1.3/KCNA3 (Kd=40 uM), Kv1.6/KCNA3 (16.6% inhibition at 40 uM toxin) (PubMed:12034709, PubMed:23726856, PubMed:27578329). The block is dose-dependent, voltage-independent, and reversible (PubMed:12034709). Also shows a weak inhibitory activity on the plant pathogen F.culmorum growth (IC(50)=18.8-37.7 uM) (PubMed:27578329).

EXTERNAL LINKS

uniprot
enzyme classification

KKX11

Potassium channel toxin kappa-KTx 1.2

Mutations

Mutation(s) distribution

Mutations table

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