FEATURES

FAMILY

DESCRIPTION

Also known as TXMG5_MACGS, TXMG5. Insect and vertebrate active toxin. Binds to site 4 of mammalian voltage-gated sodium channels and shifts the activation voltage of the mammalian Nav1.2a/SCN2A channel to more hyperpolarized voltages, whereas the insect channel, DmNav1 (para), is not affected. Competes for binding at site 3 of the insect sodium channel. Causes temporary paralysis when injected into lepidopteran larvae at 8.6 nmol/g. A low intracranial injection dose into mice causes lacrimation, closure of the eyes and sweating. A high injection dose causes extensive lacrimation and death.

EXTERNAL LINKS

uniprot
enzyme classification

TXMG5

Mutations

Mutation(s) distribution

Mutations table