FEATURES

FAMILY

DESCRIPTION

Also known as H32_MOUSE, H3c2, H3c3, H3c4, H3c6, H3c7, H3c13, H3c14, H3c15, H3-53, H3.2, H3b, Hist1h3b, H3-143, Hist1h3c, H3-B, Hist1h3d, H3-F, Hist1h3e, H3.2-221, H3f, Hist1h3f, H3.2-616, Hist2h3b, H3.2-615, Hist2h3c1, Hist2h3ca1, H3.2-614, Hist2h3c2, Hist2h3ca2. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer (By similarity). Interacts with DNAJC9, CHAF1A and CHAF1B (By similarity).

Also known as H32_MOUSE, H3c2, H3c3, H3c4, H3c6, H3c7, H3c13, H3c14, H3c15, H3-53, H3.2, H3b, Hist1h3b, H3-143, Hist1h3c, H3-B, Hist1h3d, H3-F, Hist1h3e, H3.2-221, H3f, Hist1h3f, H3.2-6 ...

EXTERNAL LINKS

H3c2, H3c3, H3c4, H3c6, H3c7, H3c13, H3c14, H3c15

Histone H3.2

H3c2, H3c3, H3c4, H3c6, H3c7, H3c13, H3c14, H3c15

Molecular Synopsis