FEATURES

FAMILY

DESCRIPTION

Also known as H32_CHICK, H3-I, H3-II, H3-III, H3-IV, H3-V, H3-VI, H3-VII, H3-VIII. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

EXTERNAL LINKS

H3-I, H3-II, H3-III, H3-IV, H3-V, H3-VI, H3-VII, H3-VIII

Mutations

Mutation(s) distribution

Mutations table