FEATURES

FAMILY

protease inhibitor I3 (leguminous Kunitz-type inhibitor) family

DESCRIPTION

Also known as ITRY_ENTCO, ITRY. Inhibits trypsin and chymotrypsin with a 1:1 stoichiometry, with dissociation constants of 1.56 nM and 120 nM respectively. Inhibits plasma kallikrein, factor XIIa and plasmin with dissociation constants of 5.0 nM, 150 nM and 18 nM respectively. Does not inhibit factor Xa, thrombin, tissue kallikrein or cysteine proteinases such as papain and bromelain. Heterodimer of an alpha and a beta chain linked by a disulfide bond.

EXTERNAL LINKS

uniprot
enzyme classification

ITRY

Mutations

Mutation(s) distribution

Mutations table