FEATURES

FAMILY

class-I pyridine nucleotide-disulfide oxidoreductase family

DESCRIPTION

Also known as TRXR1_DROME, Trxr-1, GR. Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

Trxr-1

Mutations

Mutation(s) distribution

Mutations table