FEATURES

FAMILY

isocitrate and isopropylmalate dehydrogenases family

DESCRIPTION

Also known as LEU32_ARATH, IMDH2, IMD2, IMDH, IPMDH2. Involved in leucine biosynthesis; catalyzes the oxidative decarboxylation step in leucine biosynthesis (primary metabolism) (PubMed:21697089). Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate, 3-IPM) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (PubMed:15849421, PubMed:20840499). Required during pollen development and involved in embryo sac development (PubMed:20840499). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

IMDH2

3-isopropylmalate dehydrogenase 2, chloroplastic

Mutations

Mutation(s) distribution

Mutations table

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