FEATURES

FAMILY

two pore domain potassium channel (TC 1.A.1.8) family

DESCRIPTION

Also known as KCNK2_MOUSE, Kcnk2. Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2 (PubMed:24496152). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (PubMed:24496152). Homodimer; disulfide-linked (PubMed:24496152). Heterodimer with KCNK1; disulfide-linked (PubMed:24496152). Interacts with BVES; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (PubMed:22354168, PubMed:26642364).

EXTERNAL LINKS

Kcnk2

Mutations

Mutation(s) distribution

Mutations table