FEATURES

FAMILY

DESCRIPTION

Also known as KALRN_RAT, Kalrn, Duo, Hapip. Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation. Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG (By similarity).

Also known as KALRN_RAT, Kalrn, Duo, Hapip. Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal ...

EXTERNAL LINKS

uniprot
enzyme classification

Kalrn

Kalirin

Kalrn

Molecular Synopsis