FEATURES

FAMILY

DESCRIPTION

Also known as CYC_HUMAN, CYCS, CYC. Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain., Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

EXTERNAL LINKS

CYCS

Cytochrome c

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

CYCS

Structural Ligandability

Domains Chains

Distribution