FEATURES

FAMILY

DESCRIPTION

Also known as WHIB1_MYCTU, whiB1. Acts as a transcriptional repressor, inhibiting expression in vitro. Probably redox-responsive. The apo- but not holo-form binds to its own promoter as well as that of groEL2. Oxidized apo-form and nitrosylated holo-form also bind DNA. The apo-form has been shown to act as a protein disulfide reductase (PubMed:17157031) (PubMed:19016840), but also not to act as a protein disulfide reductase (PubMed:20929442). Homodimer. Interacts with GlgB via an intermolecular disulfide bond.

EXTERNAL LINKS

uniprot
enzyme classification

whiB1

Mutations

Mutation(s) distribution

Mutations table