FEATURES

FAMILY

DESCRIPTION

Also known as DPDS_MYCTU, uppS. Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z, 6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans, polycis-decaprenyl diphosphate. When (2E, 6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and (2E, 6E, 10E)-geranylgeranyl diphosphate (EEE-GGPP) are synthesized. M.tuberculosis does not synthesize (2E, 6E, 10Z)-geranylgeranyl diphosphate (EEZ-GGPP) and heptaprenyl diphosphate. Can also accept many different allylic substrates, including E-geranyl diphosphate (E-GPP), neryl diphosphate (NPP), and all-trans-geranyl-geranyl diphosphate. Homodimer.

EXTERNAL LINKS

uppS

Decaprenyl diphosphate synthase

uppS

Molecular Synopsis