FEATURES

FAMILY

DESCRIPTION

Also known as THYX_MYCTU, thyX. Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5, 10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant (PubMed:18493582). Is essential for growth of the pathogen on solid media in vitro; the essential function is something other than dTMP synthase (PubMed:12657046) (PubMed:22034487). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

thyX

Flavin-dependent thymidylate synthase

Mutations

Mutation(s) distribution

Mutations table

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