FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as MABA_MYCTU, mabA, fabG1. Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis (PubMed:11932442). Catalyzes the NADPH-dependent reduction of beta-ketoacyl derivatives, the second step of the FAS-II elongation cycle (PubMed:9802011, PubMed:11932442, PubMed:17059223, PubMed:18155153, PubMed:19685079). May preferentially metabolize long-chain substrates (C8-C20) (PubMed:11932442). Can use CoA derivatives as substrates in vitro (PubMed:9802011, PubMed:11932442, PubMed:17059223, PubMed:18155153). Homotetramer (PubMed:11932442, PubMed:12079383, PubMed:15977159, PubMed:17642518). Homodimer in solution (PubMed:17059223, PubMed:18155153).

EXTERNAL LINKS

mabA

Mutations

Mutation(s) distribution

Mutations table